Excerpt from "NIH-funded researchers present preliminary clinical trial results suggesting aggressive blood pressure control may lower risk of cognitive impairment," posted on NIH News, July 25, 2018.
Preliminary findings from a large clinical trial, the Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition IN Decreased Hypertension (SPRINT MIND) study will be presented at the Alzheimer’s Association International Conference in Chicago on July 25. The findings suggest that intensive lowering of blood pressure may reduce the risk of mild cognitive impairment (MCI) and the combined risk of MCI and dementia, but not dementia alone. The SPRINT MIND study was funded by the National Institutes of Health.
The participants in SPRINT were adults at high risk for cardiovascular disease and the study previously reported that aggressive blood pressure control reduced cardiovascular events and mortality. In addition to the reduction in the risk of cognitive impairment, the SPRINT MIND preliminary results also suggest that intensive blood pressure control significantly lowered increases in cerebral white matter abnormalities as seen on MRI among a subgroup of participants without diabetes. These abnormalities have been reported to increase the risk of cognitive impairment and dementia.
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