Excerpt from "NIH research program to explore the transition from acute to chronic pain," posted on NIH News, August 28, 2018.
The National Institutes of Health has launched the Acute to Chronic Pain Signatures (A2CPS) program to investigate the biological characteristics underlying the transition from acute to chronic pain. The effort will also seek to determine the mechanisms that make some people susceptible and others resilient to the development of chronic pain. A2CPS is part of the NIH-wide HEAL (Helping to End Addiction Long-term) Initiative, an aggressive, trans-NIH effort to speed scientific solutions to stem the national opioid public health crisis. The high prevalence of chronic pain in the United States, and the reliance on opioids for its management, has created an urgent need for safer, more effective pain control. Though A2CPS is part of the HEAL Initiative, its anticipated $40.4 million four-year budget is supplied by the NIH Common Fund, and is an additional investment to enhance research on pain and opioid addiction beyond funds already allocated to HEAL.
A major challenge in pain care is to prevent chronic pain from developing after an initial painful event. For most people, pain goes away as an injury heals. For many others, the pain persists beyond healing of the initial event, and can last for years or even a lifetime. Changes that occur in the body and brain during the development of chronic pain are poorly understood.
“Our lack of understanding of how acute pain becomes chronic pain has limited our ability to target effective preventive and treatment strategies to patients,” said NIH Director Francis S. Collins, M.D. Ph.D. “The ability to identify those at risk will increase our understanding of pain, accelerate therapy development, and ultimately may guide chronic pain prevention strategies tailored for those at risk for chronic pain.”
The A2CPS program will collect data from patients with acute pain associated with a surgical procedure, and patients with acute pain from a musculoskeletal trauma such as a broken bone. Neuroimaging, high-throughput biomedical measurements, sensory testing, and psychosocial assessments collected periodically after the acute pain event will form a comprehensive data set to help predict which patients will develop chronic pain.
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